Schupp N, Schmid U, Heidland A, Stopper H. The researchers cultured human endothelial cells in normal and very high glucose concentrations, treating them with benfotiamine or thiamine, and measuring the cells' survival and rates of healthy reproduction. Dec;11(4):294-329. Rounding out the basic sugar nomenclature are the O-glucans and N-glucans. Remarkably, similar results were also found in the benfotiamine treatment group-but not in the thiamine-treated animals. Beneficial effect of lysine and amino acids on cataractogenesis in experimental diabetes through possible antiglycation of lens proteins[J]. Experimental Eye This was a six-week-long, open trial among 36 subjects ranging from 40 to 70 years old whose diabetes was under reasonably good control. Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options. When a glucosidic linkage is found through an oxygen molecule, it is called an O-glucan, whereas a glucosidic linkage found through a nitrogen molecule is called an N-glucan. The formation of advanced glycation end products (AGEs) is an important biochemical abnormality that accompanies diabetes mellitus and, likely, inflammation in general. Shangari N, Mehta R, O'brien PJ. Yonei Y, Miyazaki R, Takahashi Y, et al: Anti-glycation effect of mixed herbal extract in individuals with pre- diabetes mellitus: A double-blind, Jun;1043:718-24. ompanies. Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine. J Biol Chem. Let me try to explain it to you in a simple way. Benfotiamine also cut AGE production in the high-glucose environment from 160% of normal to similar levels found in healthy glucose-exposed cells. Role of advanced glycation end products in diabetic A therapeutic strategy to prevent and ameliorate diabetic neuropathy using anti-AGE agents needs to be Diabetes Obes Metab. Feb;10(2):99-108. Jun;6(4):453-74.
Anti glycation diabetes
Therefore, foods containing proteins that are rich in lysine residues such as milk proteins are likely to brown readily. Sep;4(3):154-9. The skin care guru adds that it is even more important to reverse the damage to skin caused by glycation, which became possible only recently. Jan 30;165(2):146-54. Because carnosine structurally resembles the sites that glycating agents attack, it appears to sacrifice itself to spare the target. J Am Coll Cardiol. Glycation can be described as the binding of a protein molecule to a glucose molecule resulting in the formation of damaged, nonfunctioning structures. Feb;34(2):47-50. Inhibition of The Molecular Mechanism of Diabetes By Natural And Synthetic Antiglycation AgentsNot AvailableJahan, Humera. This -C-O-C- group is formed when the two sugars come together and eliminate a molecule of water. The researchers concluded that benfotiamine is effective even in the medium-dose range, but that maximum benefits would be found with higher doses. Dec 7;44(11):2137-41. Our rapidly expanding experience with the diabetic population has taught us that the AGE-related damage to tissues involves a specific chemical receptor that responds to the presence of AGE molecules by inducing inflammation. Biochemistry Mike Cooper. Dr. Steven Vik November 16, 2001. A Mini-Review - Glycation and Protein Cross-linking. Glycation is the non-enzymatic addition or All patients experienced significant improvements in pain and vibration sensation, as well as in objective measurements of nerve function, with most improvements being evident by the third week of the study. Building on the basic forms of sugar chemistry, this article now considers their interactions. Negrean M, Stirban A, Stratmann B, et al. Endocrinology. We have come a long way in a few short years of nutritional research. Many of the fine processes involved in glycation remain to be discovered. Natural Products as Anti-glycation Agents: Possible Therapeutic Potential Diabetes mellitus is Data for forty two plants/constituents studied for anti Figure 4 shows the steps of the Maillard reaction, which follow several pathways depending on the type of reactants or ingredients, the temperature and the pH. Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes. Marchetti V, Menghini R, Rizza S, et al. Wu S, Ren J. When sugar reacts with protein in a nonenzymatic manner, it forms AGEs that are harmful to the body. These researchers concluded that benfotiamine is the best form of thiamine for therapeutic use. http://tiotricaminqua.exteen.com/20160704/pills-for-diabetes-type-2-8-as-a-decimal Inhibitors of advanced glycation end product-associated protein cross-linking. Dec;147(12):5967-74. New approaches for the treatment of genomic damage in end-stage renal disease. Here, we'll explore how to use benfotiamine to help protect against the dangers of elevated blood sugar and toxic glycation reactions. Arq Bras Endocrinol Metabol. Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha.
This basically is an amine-assisted dehydration reaction of sugar, meaning water is formed and the condensation product rapidly loses water as the product is converted into a Schiff base. Using antioxidants and topical moisturizers are a good start to keeping the effects of aging at bay, but they only go so far, Cummings says. Giusti C, Gargiulo P. Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes. The answer is based on the concept of bioavailability-not all beneficial molecules are equally well absorbed from the digestive tract, and once absorbed, they may be extensively metabolized and/or poorly penetrate target tissues. Marsche G, Weigle B, Sattler W, Malle E. Comparative autoradiographic investigations on the tissue distribution of benfotiamine versus thiamine in mice. The scientists then measured tissue indicators of cell death and destruction. Figure 7 shows how both glyoxal and methylglyoxal can be produced from glucose without going through the whole Maillard reaction. Nov;33(4):615-21. online (etc) Andersen CA, Roukis TS. Altern Med Rev.
Sanchez-Ramirez GM, Caram-Salas NL, Rocha-Gonzalez HI, et al. The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort. Int. J Clin Pharmacol Ther. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. For instance, AGEs can link up with proteins and denature or alter them to become nonfunctional, cross-linked collagens, which cause stiffness of the skin. Dec;31(Pt 6):1423-5. Limited Time Offer, Buy It Now! Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. Most recent research suggests that the most important action of carnosine is its anti-glycation effect (Aldini et al 2002a, 2002b, Yeargans and Seidler 2003). There are at least five critical steps to forming AGEs, the first two of which are related to sugar content and are spontaneously reversible. Int J Clin Pharmacol Ther. J Clin Invest. Clinical and prognostic value of advanced glycation end-products in chronic heart failure. Robert L, Robert AM, Fulop T.
These researchers concluded that timely administration of benfotiamine was effective in prevention of functional damage and of AGE formation in nerves of diabetic rats-a radically promising finding! Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD). Apr;36(4):216-21. Hartog JW, Voors AA, Schalkwijk CG, et al. The authors were understandably exuberant in their concluding statement, We have demonstrated, for the first time, that benfotiamine aids the post-ischemic healing of diabetic animals.. Elastin is another long-lived protein that is easily glycated and lasts a long time, and denatured elastin is associated with slackened skin. Anti-glycation, Whitening, Anti-ageing AGEs has been shown to contribute to the progression of age-related diseases and diabetes. Glycation of collagen and The chemistry of these compounds is not well-known but some of the reactions are included in the references. http://illirimanni.exteen.com/20160904/gluco-lodge-jobs Aside from benfotiamine's anti-glycation effect, it also appears to protect enzymes, heal damaged nerves, If you have metabolic syndrome or diabetes, Benfotiamine relieves inflammatory and neuropathic pain in rats. Nov;23(8):600-11. Playford DA, Watts GF. Das Reaktionsprodukt wird auch als Advanced Glycation Endproduct (AGE) bezeichnet. z. B. Diabetes mellitus Typ II und Herz-Kreislauferkrankungen. Glycation (sometimes called non-enzymatic glycosylation) enables medium-term blood sugar control to be monitored in diabetes. See also Wiad Lek. 2006;59(5-6):383-7.
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. May;85(5):1236-43. These two end products have been found to interfere with biochemical substances and reactions, one in particular being DNA.8, 9 Both glyoxal and methylglyoxal damage DNA in intact cells; glyoxal is able to produce DNA strand breaks while methylglyoxal is responsible for DNA protein cross-linking that results in nuclear condensation and the inactivation of some sections of DNA. Amino Acids. Feb;49(2):405-20. And Indian researchers recently demonstrated the potential anticancer activity of thiamine.24 They discovered thiamine to be one of the B vitamins that blocks the production of free radicals by AGE molecules, which in turn prevents dangerous DNA injury that can lead to cancer initiation. company. To better understand the process of glycation, it would first be helpful to review some sugar chemistry and the pathophysiology of glycation. Diabetes. 2003 Aug;52(8):2110-20. Nov;39(11):1263-8. Diabetic rats, not treated with glycation inhibitors, show a twofold increase in glomerular staining for advanced-glycation end products compared with a similar group of diabetic rats receiving treatment (Forbes et al, 2001). May;9(3):233-45.
