Zhou JH and Liu GZ, eds, Recent Advances in Chinese Herbal Drugs, 1991; Science Press, Beijing, China. Table 3: Some Herbs Recently Mentioned as Having Potential for Drug Interactions. As with the foods, the potential for the herbs to cause an unfavorable interaction with MAOI drugs is based on their dosage: if the amount is high enough, a reaction might occur; in lower dosage, no significant reaction is expected. One doesn't know, without extensive research, what dosage is necessary to cause a problem. Koupparis LS, Harmless herbs: a cause for concern?, Anesthesia, 2000; 55(1): 101-102. State Administration of Traditional Chinese Medicine, Advanced Textbook on Traditional Chinese Medicine and Pharmacology, (vol. In mice, it was found that MAO activity of brain mitochondria was much higher in senile mice than in young mice, thus providing a model for studying the changes that take place in humans when herbs are consumed (10). The antiaging Essence-Restoring Decoction was shown (11) to lower the MAO levels in senile mice brain mitochondria: the formula is comprised of herbs such as raw rehmannia, astragalus seed, cynomorium, cuscuta, ho-shou-wu, dipsacus, achyranthes, ligustrum, and morus fruit. Fortunately, regular administration of the formula to persons over age 60 for a year produced none of the typical MAO inhibitor drug side effects, but instead alleviated problems of fatigue, low appetite, insomnia, and night time urination. According to one recent literature review, it was suggested that patients try to limit their vitamin K intake from their diet to 65-80 micrograms (15). The current recommended daily requirement for adults not undergoing warfarin therapy, is 65 micrograms for women and 80 micrograms for men; thus, the recommendation is to avoid exceeding the levels suggested for normal nutritional needs. Vitamin K is produced by intestinal bacteria; use of antibiotics that inhibit intestinal bacteria can also change the vitamin K content of the patient's blood. During the past decade, it has become standard procedure to place patients who have survived a heart attack or stroke on a regimen of daily use of blood thinning drugs (e.g, warfarin). These drugs are also used in other circumstances where it is feared that a clot may form, such as after leg surgery (a clot forming as a result of the surgical damage could release and migrate to the brain). The drugs don't actually make blood thinner, but reduce the ability of its platelet component to clot (the clumped platelets represent a thickening of the blood). The drugs are administered with the intent of preventing a harmful or catastrophic clot. The dose of the anticoagulant must be adjusted carefully so that there is adequate clotting at the site of an injury, otherwise, the person could seriously bleed (even to the point of fatality) from a relatively minor cut or from a bleeding ulcer. Yet, there must be enough impairment of unnecessary clotting that a heart attack or stroke is unlikely to occur. One of the fears associated with use of blood thinning drugs is the possibility that the patient will suffer from a cerebral hemorrhage. This is a rare event, but unlike bleeding from a cut that might simply stop a little more slowly under the influence of the drug compared to normal, even the small amount of blood flow in a cerebral hemorrhage can be fatal. Usually, platelet aggregation rates of the patients on blood thinning regimens are measured weekly, so as to assure that the rate is within desired bounds; if it is not, the drug dosage can be changed or factors that are influencing it can be removed. In contrast to conventional medications, unconventional treatments (such as herbs) have little or no actual scientific basis so doctors can guide their patients regarding proper usage or potential toxicity. These side effects are described and reported after drug trials and research studies have been conducted. John's wort was also blamed for a sharp drop in cyclosporin availability (30); since this drug is used to prevent transplant rejection, a lowered blood level could lead to initiation of the rejection reaction, which may be difficult to reverse. On the other hand, the herb has also been reported to inhibit CYP3A4 (31), which could result in some drugs being made available to the blood at elevated levels. Glucolon diabetes treatment These medications regularly contain virtually uniform quantities and ratios of substances. Information about drug components, interactions, usage in pregnancy, while breastfeeding, for pediatric patients, and dosing limits are outlined and made available in standard references for doctors treating patients.
Glucolo herbal medicine interactions
2012年6月13日 - How Does It Work Glucolo is a 100% natural herbal medicine and is made from herbs like gymnema sylvestre and emblica officinale which are pr If the patient or the patient's doctor (who has prescribed the drug) indicates that there is a substantial worry about herb-drug interactions, then it is best not to prescribe herbs. It is likely, in such cases, that any apparent adverse event would first be blamed on the potential interaction, with interruption of the planned herbal therapy anyway. By contrast, it is normal for a patient or doctor to simply raise a question about this matter, and, if the herb prescriber has taken the possibilities of interactions into account, one can usually proceed with an herbal therapy under the guidelines described here. One way to assess the reasonable degree of concern for any herb-drug interactions is to consider what the consequences might be of a small, but significant, increase or decrease in the level of the drug(s) that the patient is taking. Changes in drug levels appear to be the most common outcome of herb-drug interactions and might still occur to a limited extent while taking the above-mentioned precautions. If the result of the modest change in drug levels is something that is easily reversed by ceasing use of the herbs or by altering the dose of the drugs, then the risk is low and one can proceed to utilize the herb therapy; if the consequence of change is irreversible or potentially catastrophic, then the risk is high and it is better to avoid the herb therapy. It is fairly common that persons with serious heart disease will take three or more cardiac drugs (e.g, an antihypertensive, an anticoagulant, and an antiarrhythmic or heart stimulant). Since even small changes in the activity of these drugs could lead to serious consequences, one would have to consider the situation one of high risk and uncertainty, and avoid the use of herbs. Bailey DG, et al, Ethanol enhances the hemodynamic effects of felodipine, Clinical Investigations in Medicine 1989; 12(6): 357-362. Piscitelli SC, et.al, Indinavir concentrations and St. By using this website, you agree to the use of cookies. Vito Mol is online store of herbal medicine. Order the best herbal supplements and other herbal health products. Walgreens osmo patchGeneric drospirenone-ethinyl Many Chinese herbs have been reported to be useful in the treatment of autoimmune disorders. One mechanism of action is to enhance the circulating levels of corticosteroids by slowing their metabolism. This action will not only increase the amount of natural corticosteroids (hormones produced by the adrenal cortex), but also any steroids administered as drugs. When the steroid levels administered for treating inflammation are high enough to cause some side effects, elevation of the drug level by herb action could increase the side effects. The sex hormones are metabolized by both the same and by similar enzymes as the corticosteroids. Enhanced levels of sex hormones in aged individuals may be one of the mechanisms by which antiaging Chinese herbs are able to improve patient conditions. The enhancement may arise at the level of hormone production or by inhibition of hormone degradation. If hormone degradation is slowed, administered hormones may be present in amounts higher than expected. This situation is similar to that which arises with inhibition of the CYP enzyme system. Tyramine, a monoamine, is broken down by MAO; the inhibitor drugs thus increase tyramine levels and catecholamines (part of the group of stress hormones), sometimes to the point that serious adverse effects occur, such as hypertensive crisis. The medical literature is full of reports claiming that MAOI diets often went too far (9), being overrestrictive and preventing people from using the drug that would be most effective for them. Avoiding pepperoni pizza with beer from the tap is a reasonable restriction, but there are very low levels of tyramine in many foods that were being restricted under some dietary recommendations. Still, the fears of interactions with MAOIs ran high as a result of the overly strict dietary concerns, and when people on these limited diets thought about or mentioned to their doctors the use of herbs, the question arose: do the herbs also interact? Among Western herbs, it has been suggested that Scotch broom (Cytisus scoparius) should be avoided with MAO inhibitors due to its content of tyramine. Rehmannia has been shown to antagonize the suppressing effect of steroids on the hypothalamic-pituitary-adrenal axis: in rats treated with the drug dexamethasone, rehmannia was able to prevent the inhibition of corticosterone production by the adrenals (20). A combination of anemarrhena, raw rehmannia, and licorice was tested in rabbits that were administered dexamethasone, and the plasma cortisone levels rose (21). WebMD Interaction Checker; How It Works; Print DISCLAIMER: The information contained This tool may not cover all possible drug interactions. In the 10 years that followed, numerous drugs were found to respond the same way to grapefruit juice (100 medical journal articles around the world either described new findings of drug interaction or reviewed the growing number of cases). Table 4: Information for Practitioners to Relay to Patients about Interactions with Drugs. The interactions depicted here may involve foods, herbs, or nutritional and non-nutritional supplements; the information stated in terms of herbs should be applied to any substance with a potential for drug interactions. Order! The transition from herbs to drugs was accelerated by the two World Wars that interrupted the international trade in herbs, making local manufacture of synthetics appear particularly attractive. The period from 1945 through 1975 was one of rapid development for advanced chemical technologies; there was an intensive effort made to produce new synthetic drugs, with the result that the majority of natural products declined in use. Although there are still about 25% of drugs that owe their active ingredients to plant materials in some way (a figure often cited by herb proponents to illustrate the value of herbs), increasingly, the relationship is remote: the drugs may have started out as isolates from herbs (or modified isolates, as with aspirin) but then became synthetic compounds. By 1975, the reliance on herbs in developed countries had declined to its lowest level. The development of new synthetic drugs continued.
gluco lodge jacket glucose kit glucolo herbal medicine 513 antidiabetic herbalThere may be unwanted interactions with prescribed medicines or other side Obach RS, Inhibition of human cytochrome P450 enzymes by constituents of St. Review common herbal supplements and some important drug interactions that may occur when herbal supplements are combined with prescription medications. Physicians must be alert for adverse effects and drug interactions associated with herbal remedies, and they should ask all patients about the use of these products. Patients who are in fragile health and using multiple drug therapies should avoid most herbs. In order to more skillfully combine drug and herb therapies, it behooves the practitioner to learn as much as possible about the mechanisms of action of both the drugs and the herbs (pharmacological action, not the action in ancient terminology). Increasingly, this is the language used to describe potential interactions that might be avoided. When patients report that they have had an experience that they believe might be the result of an interaction between one or more drugs that they are taking and the herbs that have been prescribed, it is very helpful to be able to know the possibilities that are present for such interactions. It is reassuring to the patient if they know that the potential for any herb-drug interactions has been carefully considered in selecting or designing the herb therapy (see Table 4). As a more specific example, a formula for promoting digestion might include the herb astragalus, which is used in clinical practice both as a means of promoting digestive functions and as an immune enhancing agent. A few pills of Buzhong Yi Qi Wan or Guipi Wan might effectively promote digestive functions, but would have little effect on immunity; the total daily dose of astragalus when using these pills could be about 1 gram. By contrast, an immune enhancing formula aimed at counteracting the side effects of cancer therapies might be made with a decoction that included astragalus at 15 grams per day. Although it is not always possible to directly compare the dosage used in decoctions versus pills (due to differing availability of active constituents in the two preparation methods), the large difference in dosage suggests that there will be a difference in therapeutic effects. Further, by studying the other ingredients in the formulas, one will find an additive effect on digestion for the aforementioned pills, and an additive effect on immune functions for the decoction to be used with cancer therapies. Therefore, one can expect the treatment for digestive functions to be unlikely to cause an undesired effect on the drug therapy for suppressing immune functions. However, one would be concerned about the possibility that the immune-enhancing prescription at full dosage would counteract the desired immunosuppressive drug therapy. It is important for practitioners to know the ingredients of the formulas they prescribe (not just what the formulas are indicated for) and to know the dosing patterns common to Chinese medical practice (so as to distinguish low and high dosage ranges). There are no standardized references and most of the herbal formulations have not been analyzed, are not uniform, and have not been quality controlled. Table 1: Chinese Herbal Concept of Interaction of Drugs. http://cerecontunmo.exteen.com/20160814/glucolo-herbal-medicine-healing
Neuvonen PJ, Interactions with absorption of tetracyclines, Drugs 1976; 11(1): 45-54. Limited Time Offer, Buy It Now! Hiroshi Hikino, Constituents and physiological activities of anemarrhena, International Journal of Oriental Medicine 1991; 16 (1): 17-23.
Fukuda K, et al, Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction, Pharmacogenetics 1997; 7(5): 391-396. Furanocoumarins (also called furocoumarins and sometimes designated psoralens, after one of the best known furanocoumarins) and compounds of similar structure are found in several Chinese herbs (see Table 2). Therefore, the use of the herbs with the same drugs that interact with grapefruit juice could produce the same results, at least if the herb dosage yields a similar amount of the enzyme-inhibiting compounds as grapefruit juice. Further, other substances in herbs (as yet unidentified) could inhibit the same or other drug metabolizing systems, thereby causing the increase in drug absorption. Previously, it had been thought that flavonoids (e.g, naringin) in grapefruit juice were responsible for its action on drug levels; however, it was found that the flavonoids were not present in sufficient quantity to account for the effects noted. High levels of flavonoids are provided in some herbal remedies, and might, in such cases, account for significant inhibition of CYP. Some medical doctors and pharmacists have advised that, until more is known, herbs not be mixed with drugs at all (23, 29), citing as examples several potential cases of interactions. A Chinese physician has expressed theoretical concerns about herb-drug interactions, especially with regard to antibiotics (27). For example, he suggested that antibiotics that are somewhat toxic to the liver, such as chloromycetin, erythromycin, tetracycline, riampicini, and rimifon, might become more toxic in the presence of hydrated tannins, as found in pomegranate rind, sanguisorba, gall (webeizi), and terminallia. The general concern is that the herbs have a mild liver toxicity that reinforces that of certain drugs. This might also apply to other herbs (without tannins) that are safe in normal usage but which become liver toxic in high dosage, such as xanthium. He also expressed concern over combining antibiotics with herbs rich in organic acids or alkaline substances (may change absorption characteristics of antibiotics), with herbs containing cyanosides (such as apricot and peach seeds; may cause respiratory inhibition), enzymes (as found in gallus, which may break down the drugs), licorice (decrease absorption), and blackened herbs (as used to stop bleeding, may decrease absorption of drugs). Table 3 provides a summary of some potential interactions for herbs used in the Chinese tradition; St. Bupleurum and Hoelen Combination (Chai Ling Tang) has been used extensively in Japan to aid withdrawal from corticosteroid therapy and then to serve as a replacement for that therapy in the treatment of rheumatoid arthritis, viral hepatitis, and nephritis (18, 19). By using this formula along with steroid therapy, the dose of the steroids can be reduced by two-thirds. It is also reported to reduce the withdrawal symptoms and relieve the arthritic, hepatic, or nephrotic inflammation. Part of the action is attributed to improvements in adrenocortical function, increasing the total production of the body's steroids. This formula contains, among other ingredients, saponins in ginseng, jujube, licorice, and bupleurum that are likely to contribute to this action. The formula is made from Minor Bupleurum Combination (mentioned previously), by adding cinnamon twig and four diuretic herbs (hoelen, alisma, atractylodes, and polyporus). More importantly, doctors ask if the herbs also inhibit MAO. In fact, one of the positive advantages of antiaging Chinese herbs is considered by Chinese researchers to be their MAOI activity. This is because there is an increase in MAO activity with aging, leading to a decrease of the neurotransmitters: the result is impaired mental functions. http://illirimanni.exteen.com/20160822/fda-approved-drugs-for-diabetes-type-2 Salicylic acid was obtained for drug manufacture from Spiraea plants (such as the European herb meadowsweet: Spiraea ulmaria), rather than willow bark, and given the common name spiric acid (aspirin came from acetyl-spiric-acid). Although acetylsalicylic acid was discovered in 1845, it was not marketed as a drug until 1900. In the interim, numerous patent medicines, mostly fraudulent products made with alcohol and some herbal flavorings, were sold to the public as remedies for numerous ailments. When finally marketed, aspirin simply replaced any traditional herb or herbal combination or patent remedy that was used for the same purposes (e.g, alleviating pain, inflammation, and fever). The replacement took place almost everywhere in the world, including countries with well-established traditional medical systems, such as China and India, which simply produced their own aspirin rather than importing it. Aspirin became the most widely used drug in the world. A formula used in treatment of neurological and psychiatric diseases that is not classified as an essence tonic, Minor Bupleurum Combination, was tested on MAO of rat liver mitochondria (15). Not only did it inhibit MAO, but each of its ingredients used individually also inhibited MAO, with the highest activity in licorice, pinellia, bupleurum, and codonopsis. This formula was suggested to have interactions with interferon in persons treated for hepatitis C who have severe liver cirrhosis (see: Update on hepatitis C treatments).
Lowin KS, et al, Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression, Journal of Clinical Investigations, 1997; 99: 2297-2298, 2545-2553. Glucolo herbal pills for controlling diabetes have become quite popular in recent past amongst diabetes sufferers mainly due to their quick Miller LG, Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions, Archives Internal Medicine 1998; 158(20): 2200-2211. The Drug Interaction Checker explains the mechanism of each drug interaction, the level of significance of the interaction (major, moderate or minor), and in certain cases, can provide the recommended course of action to manage the interaction. company. Effect of food, milk, and iron, Journal of the American Academy of Dermatology 1985; 12(2, Pt 1): 308-312. During the past five years, a few herbs that had been widely popularized (partly because new labeling laws allowed medical use claims to accompany their sale), such as ginkgo, ginseng, and St. Wang Zhiqiang, Toxicity and adverse effects from combining Chinese herbs and modern drugs, Practical Journal of Integrating Chinese and Modern Medicine 5(1); 7-8.
No comments:
Post a Comment